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HS-(CH2)m-EGn-N3 (TH 008)


This unique line of thiols offers a range of truly exciting surface immobilization schemes. The EG linker makes these compounds suitable for inclusion in mixed SAMs resisting nonspecific absorption (with simple EGn thiols as the background; cf. cat # TH000 - TH005), and the azide group provides a biospecific handle for Sharpless "click" chemistry. (Angew. Chem. Int. Ed. 41, 2596, 2002) towards acetylene-bearing reagents.

It has been recently been shown that the click chemistry can be used to immobilize various (bio)molecules chemoselectively and in excellent yields (J. Am. Chem. Soc. 127, 8600, 2005), and that it can be coupled with electrochemistry to allow for site-selective immobilization (J. Am. Chem. Soc. 128, 1794-1795, 2006 and also Science, Editor's Choice, 10 February, 2006). In the latter case, application of voltage bias to a gold microelectrode supporting azide-terminated SAM changed the redox state of an auxiliary copper catalyst, and thus activated the SAM for the "click" chemistry. By activating different microelectrodes at different times, it was possible to immobilize various molecules onto them. The capability of such sequential immobilization should prove extremely useful in the development of electrochemical microsensor arrays.

Note: Please see our related product Cat. FT 010-m11 (under Functionalized Thiols) and also silane analogs for functionalization of glass, Si and PDMS (under Silanes).

Standard Products

name catalog no. m n weight price
HS-C11-EG2-N3 TH 008-m11.n2-0.2 11 2 200 mg Log in to see the prices
HS-C11-EG2-N3 TH 008-m11.n2-0.5 11 2 500 mg
HS-C11-EG2-N3 TH 008-m11.n2-1 11 2 1 g
HS-C11-EG3-N3 TH 008-m11.n3-0.2 11 3 200 mg
HS-C11-EG3-N3 TH 008-m11.n3-0.5 11 3 500 mg
HS-C11-EG3-N3 TH 008-m11.n3-1 11 3 1 g
HS-C11-EG4-N3 TH 008-m11.n4-0.2 11 4 200 mg
HS-C11-EG4-N3 TH 008-m11.n4-0.5 11 4 500 mg
HS-C11-EG4-N3 TH 008-m11.n4-1 11 4 1 g
HS-C11-EG5-N3 TH 008-m11.n5-0.2 11 5 200 mg
HS-C11-EG5-N3 TH 008-m11.n5-0.5 11 5 500 mg
HS-C11-EG5-N3 TH 008-m11.n5-1 11 5 1 g
HS-C11-EG6-N3 TH 008-m11.n6-0.2 11 6 200 mg
HS-C11-EG6-N3 TH 008-m11.n6-0.5 11 6 500 mg
HS-C11-EG6-N3 TH 008-m11.n6-1 11 6 1 g

Custom synthesis variants

This product is also available on custom synthesis basis, in the following variants:

m: 8
n: 8, 12

Note, if none of the listed structures fit your specific requirements, please submit your own structure formula within our custom synthesis contact form by clicking button below.

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