Description

These methoxy-terminated EG thiols form excellent adsorption-resistant monolayers. Interestingly, studies by the Liedberg and Tengvall groups indicate that the methoxy terminus gives rise to even looser protein binding than in the corresponding SAMs with hydroxyl-terminated EG units (J. Biomater. Sci. 12, 581-597, 2001). The EG3OMe thiol was used as a background in micropatterned surfaces for optical detection of antibodies (Sensors and Actuators B70 , 232-242, 2000) and in microarray-based immunoassays (Anal. Chem. 76, 7257-7262, 2004). The EG6OMe, on the other hand, provided a basis for micropatterning of substrates for controlled propagation of viruses on host cells (Biotech. Bioeng. 81, 719-725, 2003) and for several fundamental studies of the mechanism/origin of adsorption resistivity (J. Am. Chem. Soc. 115, 10714-21, 1993; J. Biomed. Mater. Res. 56, 406-416, 2001).