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HS-(CH2)m-EGn-OCH2-COONHS (TH 005)


The reactive NHS head-group allows covalent coupling of a variety of molecules onto the monolayer. NHS-activated carboxy-terminated thiols were used, for example, to immobilize B-galactosidase (Ball, J.C. et al. Anal. Chem., 2003, 75, 6932), collagen V and horseradish peroxidase (Zaugg, F.G. et al. J. Mat. Sci Mat. Med., 1999, 10, 255). Biebuyck and coworkers (J. Am. Chem. Soc., 1998, 120, 500) have used thiols terminated with active NHS esters for covalent attachment of antibodies to SAMs for the development of immunosensors. At the same time, owing to the (ethylene glycol) linker, this thiol forms SAMs resistant to nonspecific adsorption. A truly versatile compound!

Note: Since this thiol hydrolizes readily, it should be stored in pure state, at low temperature and under inert-gas atmosphere.

Standard Products

name catalog no. m n weight price
HS-C11-EG6-OCH2-COONHS TH 005-m11.n6-0.05 11 6 50 mg Log in to see the prices
HS-C11-EG6-OCH2-COONHS TH 005-m11.n6-0.1 11 6 100 mg
HS-C11-EG6-OCH2-COONHS TH 005-m11.n6-0.2 11 6 200 mg
HS-C11-EG6-OCH2-COONHS TH 005-m11.n6-0.5 11 6 500 mg
HS-C11-EG6-OCH2-COONHS TH 005-m11.n6-1 11 6 1 g

Custom synthesis variants

This product is also available on custom synthesis basis, in the following variants:

m: 3, 5, 6, 8
n: 2-5, 8, 12

Note, if none of the listed structures fit your specific requirements, please submit your own structure formula within our custom synthesis contact form by clicking button below.

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