Just launched, great offer of unique coumarin-4-ylmethyl photocleavablethiol for UV-patterned SAMs specialists!
The photo-cleavable protecting groups are called "phototriggers"or "caging groups". Coumarin-4-ylmethyls are phototriggers with higher efficiencies than others such 2-nitro-benzyls, enabling the incident light intensity for the uncaging reaction to be lowered. It leads to minimization of protected functionality damage with maintaining higher spatial and temporal resolution. The coumarin-type cages have been successfully applied to protect phosphates [1, 2], amines , carboxylates , alcohols and phenols . The 11-sulfanylundecanoic acid 7-decyloxy-2-oxo-2H-chromen-4-ylmethyl ester (Cat No.PC 001-m10-0.05, PC 001-m10-0.1) after uncaging reaction (350 nm irradiation) provides carboxyl group at the surface of SAMs available for interaction or further functionalization.
These coumarin-type phototriggers were also applied for modification of SAMs surfaces properties [6-8]. Using irradiation with light to alter the cell adhesiveness of a substrate surface allows for patterning of cell cultures in various shapes and sizes without compromising the bioinert character of the non-irradiated regions.
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